Large symptomatic colonic lipomas require treatment, but resection of lipomas by means of endoscopic cautery snare carries some risk of colonic perforation. The loop-and-let-go technique described here is technically simple; anyone who is well acquainted with the snare cautery technique can do it. It looks safer than the conventionally employed snare cautery technique, as no current is used with the loop-and-let-go technique. It causes selective occlusive ischemia of mucosa and submucosa without causing any transmural damage. The total duration needed for the lipoma to slough off depends on the quality of endoloop occlusion and the type of lipoma (narrow-based vs wide-based).